S4-31.2 – What do we know about mechanisms of action in NASH drugs and the commercial implications?

S4-31.2 - What do we know about mechanisms of action in NASH drugs and the commercial implications?
Roger Green is joined by KOL Mazen Noureddin to discuss a complex and developing NASH therapeutic landscape and takeaways from an exciting month of meetings. This final interview with Mazen is to be followed by a series of deep-dive episodes dedicated to unpacking the 2023 EASL Congress and the 83rd annual American Diabetes Association Scientific Sessions. Stay safe and surf on!

Throughout the month of July, Surfing NASH embarks on a series of episodes dedicated to takeaways emerging from a busy last few weeks at both the 2023 EASL Congress in Vienna and the American Diabetes Association’s 83rd Scientific Sessions meeting in San Diego.

This first installment comprises two distinct 1:1 interviews with Tsunami co-host Roger Green, one with key opinion leader Mazen Noureddin and the other with co-host Jörn Schattenberg.

This second and final conversation with Mazen continues to explore what we do or do not know about the different mechanisms of action in NASH drugs and the commercial implications. Later, the Monopoly metaphor around NASH therapeutic development as described in the preceding conversation is expanded. Roger shares his interesting idea on how Big Pharma is similar to the role of Hollywood in movie production and distribution opportunities. Finally, the two discuss why it is critical to move beyond ordinal histopathology reads in the drug approval process before sharing final thoughts around what factors are contributing to an exciting future for combating liver disease.

Both conversations with Mazen and Jörn explore different perspectives around the complexities associated with drug development and the wider field’s understanding of Steatotic Liver Disease (SLD). Stay tuned for more in the subsequent conversations to be released. If you have any questions or comments around these meetings, the discussed therapeutics or the new nomenclature, we kindly ask that you submit reviews wherever you download the discourse. Alternatively, you can write to us directly at questions@SurfingNASH.com.

Stay Safe and Surf On!

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Sponsoring partnerships with SurfingMASH present a multifaceted avenue for companies seeking to amplify their brand presence and engage with targeted audiences.