S4-10.5 – From the Vault: 2022 Liver Conference: Pediatric NAFLD and Liver Health Education

S4-10.5 - From the Vault: 2022 Liver Conference: Pediatric NAFLD and Liver Health Education
This conversation From the Vault visits the 2022 Liver Conference coverage of pediatric NASH and NAFLD with guest, Naim Alkhouri.

This episode From the Vault comes from the 2022 Liver Conference, where over 400 liver disease stakeholders gathered in Scottsdale, Arizona for the event sponsored by the Chronic Liver Disease Foundation (CLDF). Episode 15.3 of Season 3 and its conversations capture some of the thinking that went into the program design and some highlights of the NASH-related sessions.

This conversation focuses on the issue of pediatric NASH and NAFLD. Naim Alkhouri discusses the urgent need to include pediatric and adolescent patients in clinical trials, while Louise Campbell asked whether we could possibly get results soon enough to help today’s youngsters with NAFLD or NASH. Marcelo Kugelmas stated his firm conviction that we need to prove safety and efficacy available, but that there are many other steps we can take (lifestyle modification, for one) if we have adequate commitment. This led Roger Green to note government action in the UK to improve the informational quality of food and fast-food restaurant advertising and to ask whether something similar could happen in the U.S. This sparked discussion about food labelling in the UK, Michele Obama’s program in the US, the impact of sugar taxes and food advertising bans during certain times of day, and the overall potential for government activities to succeed. In the end, the group agreed that with money, an advertising campaign to back these kinds of issues might have an excellent result.

This episode and conversations are sponsored by Madrigal Pharmaceuticals, Inc., a clinical-stage biopharmaceutical company pursuing novel therapeutics for NASH. Madrigal’s lead candidate, resmetirom, is a once daily, oral, thyroid hormone receptor (THR)-β selective agonist that is designed to target key underlying causes of NASH in the liver. Resmetirom is currently being evaluated in two Phase 3 clinical studies, MAESTRO-NASH and MAESTRO- NAFLD-1, designed to demonstrate multiple benefits in patients with NASH. For more information, visit www.madrigalpharma.com.

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