S3-E43.6 – Future NASH Drug Development: More Diverse Trial Populations and More Study of Combination NASH Drugs

S3-E43.6 - Future NASH Drug Development: More Diverse Trial Populations and More Study of Combination NASH Drugs
Earlier this year, the "Band" (Jörn Schattenberg, Stephen Harrison, Louise Campbell and Roger Green) got back together with no other guests to talk about the role that combination NASH drugs and greater population diversity in clinical trials will play to strengthen NASH drug development.

This conversation from The Vault is part of a broader overview of NASH drug development in 2022, led by Stephen Harrison and Jörn Schattenberg.

Future NASH Drug Development: More Diverse Trial Populations and More Study of Combination NASH Drugs

It starts with Louise Campbell asking whether design and management of the ongoing trials will provide sufficient granularity on matching patient types to medications or drug classes. Stephen Harrison notes that we have not paid sufficient attention to this issue historically. In fact, he notes a range of key variables we do not explore at baseline: genotype disease markers like PNPLA3, microbiome and non-Caucasian population segments, to name three. He also notes that some promising drugs have been killed because of trial design issues. In the end, he returns to core positive concepts: combination therapies, looking for agents with multiple positive metabolic effects and safety.

At this point in the conversation, Stephen’s transmission starts to fail. Eventually, he leaves the conversation and focus shifts to cirrhosis.

This episode and all its conversations are sponsored by Madrigal Pharmaceuticals. Conversations 25.5 and 25.6 are a two-part summary of Madrigal’s disease-focused presentation at the recent CLDF LiverConnect meeting.

Sponsoring partnerships with SurfingMASH present a multifaceted avenue for companies seeking to amplify their brand presence and engage with targeted audiences.

Sponsoring Partnerships!

Sponsoring partnerships with SurfingMASH present a multifaceted avenue for companies seeking to amplify their brand presence and engage with targeted audiences.