Stephen Harrison challenges colleagues Naim Alkhouri and Rashmee Patil to identify a “Top Ten” of criteria to consider/pressure test in designing protocols…and they come up with at least 11! In the end, Naim Alkhouri advocates for sponsors talking to trial sites, not simply CROs, during the design phase. Rashmee Patil highlights the importance of education patients and Stephen Harrison returns to the idea of designing trials that are “Good, not great”. There is a wealth of information to unpack and absorb here.