This episode asks how to reconcile results from a presentation at EASL suggesting that the primary cause of death from NAFLD patients is liver disease and the low level of CVD events in the STELLAR-3 and STELLAR-4 trials with significant other data identifying CVD as the leading cause of death in NAFLD patients. The group determined that design issues led to the low level of CVD events in the various study populations, then confirmed the importance of the link. Finally, we explored implications in terms of patient care and clinical trial design.